将含有IRES-FlpO-a LoxP介导的诺卡因筛选座的靶向构建,定位在Slc17a6基因的终止密码子下游3个碱基处。靶向的ES细胞克隆进行了扩增,并注入到囊胚中,随后杂交后代用于确认等位基因的生殖传代。通过与E2A-Cre去载体品系杂交,删除了诺卡因筛选座。(来源:J:317381)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count