Ank3^tm2.1Pmj

Tryptophan codon 1988 (TGG) in exon 37 was changed to arginine (CGG) (p.W1988R). This mutation is the equivalent of the human p.W1989R mutation found in some bipolar disorder (BD) patients. A loxP site flanked neomycin resistance gene cassette that was inserted into an intron was removed through subsequent Cre-mediated recombination. (J:329513)