设计了两个导向RNA(ATTGTGGACCATTCAGCTTG和CTTAACTATGTAGTCCAGAC),目标是定位到exon 3。非同源末端连接会导致gRNAs之间序列的缺失。参考的是Klrg1转录本Klrg1-201(ENSMUST00000032207.9),用于确定exon编号以及指导序列。(来源:J:334818)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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