Tg(Rr418-Luc)Harry1Ward

The transgene contains the following elements: Igf2 promoter 3 (Rr146; from 162 bp upstream of TSS of exon 3/alternative exon 1 [chr7:142211218 GRCm39] to 74 bp of 5' UTR in exon 3), an Igf2 enhancer from between H19 and Igf2, the luciferase reporter gene and SV40 poly(A) signal sequences. A number of independent lines were generated; this allele integrated into Sox10 enhancer sequences upstream of the gene and disrupts its expression when homozygous. The Igf2 enhancer drives expression of the reporter in the brain. (J:334634)