通过CRISPR/Cas9技术,构建了CrexER(Cre-rox-ER-rox),它由插入的两个rox序列围绕ERT2编码的cDNA实现,该cDNA替换Mki67基因的终止密码子,通过2A自切肽序列以本底Mki67基因后随。来源:(J:303771, J:339117)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count