一段编码MerCreMer(连接了两个改造后雌激素受体配体结合域的Cre重组酶)的cDNA,以及带有frt-flanked诺卡因筛选座标的序列,被插入到Acbdg2的起始密码子(含Abcg2的第二个外显子)中。在ES细胞中进行了同源重组,然后将这些杂合体与表达flp的敲入小鼠杂交,以去除选择标记。(来源:J:304949)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
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1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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