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中文
Exon 3被替换成一个带有floxed neo/STOP cassette的序列，以及一个经过修改的Exon 3，其中的GAA被替换为AAA，导致第76位氨基酸由赖氨酸变为谷氨酸（E76K），这模拟了某些儿童急性白血病和青少年单核细胞白血病（JMML）患者中发现的突变。通过Cre介导的重组，去除了floxed stop cassette。（来源：J:332221）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
