Atoh1增强子E2通过CRISPR/Cas9技术,用sgRNAs针对GAAGTTTCACTGGACACTGGAGG和AATGACAGAGGTCTTGACAGAGG位点进行了靶向,产生了890bp的缺失(chr6:64750197-64751086,GRCm39建库),包括了这个增强子,以及一个1bp的插入(C)。参考来源:J:332270

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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