Atoh1增强子E2通过CRISPR/Cas9技术,用sgRNAs针对GAAGTTTCACTGGACACTGGAGG和AATGACAGAGGTCTTGACAGAGG位点进行了靶向,产生了890bp的缺失(chr6:64750197-64751086,GRCm39建库),包括了这个增强子,以及一个1bp的插入(C)。参考来源:J:332270
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count