编码isoform 1( Romk1)的外显子被LoxP位点和PGK抗药性基因簇包围,随后在可删除的外显子下游插入了第三个LoxP位点。通过Cre介导的重组,删除了isoform 1的外显子和抗药性基因,但保留了isoform 2( Romk2)和isoform 3( Romk3)的启动子和外显子(来源:J:231022)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/SvJ
Targeted
插入,基因内删除
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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