编码isoform 1( Romk1)的外显子被LoxP位点和PGK抗药性基因簇包围,随后在可删除的外显子下游插入了第三个LoxP位点。通过Cre介导的重组,删除了isoform 1的外显子和抗药性基因,但保留了isoform 2( Romk2)和isoform 3( Romk3)的启动子和外显子(来源:J:231022)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count