将CreERT2-P2A-EGFP-SV40PA表达载体插入Htr6基因的exon 2,通过同源重组方式,导致了生殖细胞中该位置的基因失活。通过Western blot检测5-HT6R,结果显示为野生型缺失突变体。(引用:J:333280)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Endonuclease-mediated
插入
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1
--
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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