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中文
CRISPR-Cas9通过指导RNA介导的重组在位置312由A(TC)替换为C(GG)，产生了一个I到R的突变。这个氨基酸对于蛋白与TRF2和端粒的结合是必需的。细胞分拣和western blot分析显示，异源和纯合MEFs中，胞质TERF2IP蛋白水平有所增加。接下来，引入了一个沉默突变(CGG替换为CGC)到下一个密码子。(来源：J:332126)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
