CRISPR/Cas9技术产生了一个包含1-8号外显子的54,449bp缺失。qRT-PCR结果显示mH2A1.2亚型几乎没有转录表达,而mH2A1.1亚型的转录水平正常。E13.5时,皮质中检测不到表达(J:333071)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
ICR
Endonuclease-mediated
基因内删除
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1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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