这个转基因构建包含了从人类尾型同源盒2(CDX2)基因5'端序列提取的9.5kb启动子片段,一个CreERT2融合基因(连接了Cre重组酶和人雌激素受体配体结合区域),以及牛生长激素的polyadenylation序列。相较于CDX2P-CreERT2转基因#752,#741线在远端结肠上皮中展现出增强的雌激素Tamoxifen调控的Cre活性。(来源:199069)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J x SJL/J
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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