Tg(APOE-rtTA,tetO-cre)1515-3Reh

The transgenic construct is designed to have the promoter, intron 1 and hepatic control region (HCR) of the human apolipoprotein E gene driving expression of the reverse tetracycline-controlled transactivator (rtTA*M2) promoter element. The 2.8kb TRE-Cre transgenic construct is designed to have Cre recombinase under the control of tetO (tet-responsive element; TRE2). These constructs were coinjected into one-cell B6SJLF2 embryos. Both transgenes integrated at the same site in founder line 1515-3 mice. (J:332969)