这个突变是在Jackson实验室通过电穿孔Cas9蛋白和指导序列ATATGCCAAGCGGGCACCTA和AGGGCAACAGCTGTCTGCCA产生的,导致了1010bp的缺失,起点在11号染色体99,978,042bp,终点在99,979,051bp(GRCm38/mm10建库)。这个变异删除了ENSMUSE00000665201(第1外显子)的1010bp,预测会形成一个无功能的等位基因。(来源:J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
基因内删除
不确定
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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