这个转基因构建包含了tet启动子(tetO)和小鼠PrP非编码序列1-2,位于携带A53T突变的人类SNCA基因的cDNA之后,接着是小鼠PrP的非编码序列3。生成了三条高拷贝量的转基因品系,分别是hA53T-4360、hA53T-4299和hA53T-4454,其中hA53T-4360是表达量最高的。(来源:J:327648)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x C3H)F2
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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