通过CRISPR-Cas9介导的重组,这个构建包含了CAG启动子、敲除式终止子、tdTomato编码序列、3X Mir29-3p强干扰子以及WPRE序列。Mir29-3p强干扰子包含了Mir29家族成员,包括Mir29a、Mir29b-1、Mir29b-2和Mir29c的结合位点。(来源:J:313732)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
Endonuclease-mediated
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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