一个位于Fgf23骨增强因子上游的靶向区域,通过CRISPR/Cas9技术使用sgRNAs(针对CACTGGCTGGGTTCCTGGAG和AGACTTCTTAGGCTTGCGGA)被修饰,导致了3996bp的缺失。这个缺失序列包含一个可能的CTCF结合位点,名为Rr133122。(来源:J:281531)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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