心脏特异性的Scn5a增强子Rr207838,位于Exog和Scn5a之间的超增强子区域,还包括Rr207840和Rr207839,通过CRISPR/Cas9技术用sgRNAs(针对GGTCTGAGTACCGTAGATGA和GGCACTATTTGAGTTCCACT)进行了靶向,导致其删除,总共约2.3kb的序列。(来源:J:281596)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count