心脏特异性的Scn5a增强子Rr207838,位于Exog和Scn5a之间的超增强子区域,还包括Rr207840和Rr207839,通过CRISPR/Cas9技术用sgRNAs(针对GGTCTGAGTACCGTAGATGA和GGCACTATTTGAGTTCCACT)进行了靶向,导致其删除,总共约2.3kb的序列。(来源:J:281596)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/NRj
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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