这个转基因包含了大约120kb的C3H YAC ICRFy903F1113中约485kb缺失的B1重复片段。YAC包含了Gata3基因及其上游和下游调节区域,并通过在第1和2个内含子中插入LoxP位点进行了改造。诊断用的SacII酶切位点在第1个内含子,XhoI在第2个。建立了三线小鼠模型。(来源:J:51930)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
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插入
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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