PRS区域(染色体11:111446352-111723870,GRCm39),位于Sox9的topologically关联域(TAD)内,包含增强子和调控序列,通过CRISPR/Cas9技术用sgRNAs进行了靶向,导致了这一区域的删除。(来源:J:332097)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count