Cre介导的chr15染色体间重组,涉及Tn(sb-SBlac)15.184347Fsp(位于GRCm39的15:62708842-62708843)和Tn(sb-SBlac)15.193058Fsp(位于15:63225637-63225638),这次重组大约移除了517kb,保留了一个转座子元件(顺向)在缺失区域。转座子包含Sleeping Beauty转座子的倒置重复、LoxP位点、人类β-珠蛋白的HBB启动子、lacZβ-半乳糖苷酶报告基因、SV40的poly(A)信号序列,以及另一段Sleeping Beauty转座子的直接重复。被删除序列位于Myc的拓扑关联域(TAD)内,包含Myc的增强子Rr38。(参考文献:J:212391)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
Transposon induced
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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