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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Del(15Rr333-Rr313939)8Fsp
Alias:
del(G-H)
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基础信息
表型特征
文献报道
Cre介导的chr15染色体间重组,涉及Tn(sb-SBlac)15.196554Fsp(位于GRCm39的15:63564154-63564155)和Tn(sb-SBlac)15.179039Fsp(位于15:63590844-63590845),这次重组大约移除了26.7kb,保留了一个转座子元件(顺向)在缺失区域。转座子包含Sleeping Beauty转座子的倒置重复、loxP位点、人类β-珠蛋白的HBB启动子、lacZβ-半乳糖苷酶报告基因、SV40的poly(A)信号序列,以及另一段Sleeping Beauty转座子的直接重复。删除序列位于Myc的拓扑关联域(TAD)内,包含驱动元件Rr333和Rr313939。(来源:J:257739)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
7411164
Not Specified
Transposon induced
Insertion, Intergenic deletion
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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