Cre介导的chr15染色体间重组发生在15:63332129-63332130(GRCh39)区间,涉及Tn(sb-SBlac)15.192339Fsp和Tn(sb-SBlac)15.179039Fsp两个元件。这次重组大约移除了259kb,保留了一个反向排列的转座子元件在缺失点。转座子包含Sleeping Beauty转座子的倒置重复、loxP位点、人类β-珠蛋白的HBB启动子、lacZβ-半乳糖苷酶报告基因、SV40的poly(A)信号序列,以及另一个Sleeping Beauty转座子的直接重复。删除序列位于Myc的拓扑关联域(TAD)内,包含了Rr316124、Rr313933、Rr331、Rr307328、Rr332、Rr307330、Rr333和Rr313939等多个Myc增强子。信息来源(J:212391)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Transposon induced
Insertion, Intergenic deletion
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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