携带有Arg1tm1.1Lky、Il5tm1.1(icre)Lky和Il13tm2.1Lky突变的囊胚,通过CRISPR-cas9系统使用指导RNA(ACGCTCAAATTCGTCACAGGTGG和TCCTGAGCCACAGCATGTACTGG),目标是针对exon 2进行基因编辑,以创造一个无功能等位基因。(来源:J:329938)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Arg1tm1.1Lky Il5tm1.1(icre)Lky/Il13tm2.1Lky/Liah
Endonuclease-mediated
未指定
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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