CRISPR定向增强子E1(属于Wap超增强子的一部分),通过sgRNAs去除目标序列CTTCCTTGCAAGAGAAATCA和CACGTGCCCCATTGTTCTC,共删除了8个碱基(包含在内TTTCCTTG),这个区域包含了ELF5结合位点。(来源:J:330902)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
Endonuclease-mediated
基因间区删除
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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