CRISPR通过一个sgRNA(靶向TGGAAGGCCACTTCCCAGAA),移除了28个碱基(CTTCCCAGAAGGGCCCATACTGTGCCAA),这个序列包含了干扰素激活序列(GAS)和一个NFIB结合位点,位于Wap增强子上游的E1增强子区域(来自文献J:277922)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
Endonuclease-mediated
基因内删除
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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