设计了一个靶向载体,它删除了编码3个超重复序列的53-64号外显子(15,326bp的缺失,位于chr2:52,250,795-52,266,120),通过Osdd载体(提供阴性选择的TK)和同源臂(4kb左、3.5kb右),允许删除序列被FRT标记的neoR阳性选择 cassette替换。通过Flp介导的重组会移除neoR cassette。(来源:J:331852)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
基因内删除
--
1
9
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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