这个复制等位基因是通过Cre介导的染色体间重组在两个带有loxP位点的基因——Igs46em1Smun(位于GRCm39的chr11:110801622-110801623)和IIgs44tm1(sb-SBlac)Smun(含有chr11:110989101-110989102的SBlac转座子元件)之间创建的。它复制了Kcnj基因簇的一个小段Topologically Associated Domain(TAD)以及其中的Kcnj16和Kcnj2基因。(来源:J:235642)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Other
Duplication, Insertion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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