边界区域(Rr325),位于包含Kcnj16和Kcnj2基因(分别对应于TADs)以及Sox9的区域,通过CRISPR/Cas9技术用sgRNAs针对GATCATTTTAGGTAACGACCC和GATTTAGCGTCCCCTAGCATA,实现了18.342kb的删除,位置是chr11:111413371-111431712(GRCm39)。(来源:J:235642)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count