边界区域(Rr325),位于包含Kcnj16和Kcnj2基因(分别对应于TADs)以及Sox9的区域,通过CRISPR/Cas9技术用sgRNAs针对GATCATTTTAGGTAACGACCC和GATTTAGCGTCCCCTAGCATA,实现了18.342kb的删除,位置是chr11:111413371-111431712(GRCm39)。(来源:J:235642)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Endonuclease-mediated
基因间区删除
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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