CRISPR/cas9通过同源定向修复(HDR)技术,利用两个导向RNA(CACCgTACACGCTATATTTGTGCTA和AAACTAGCACAAATATAGCGTGTAc,以及CACCgTACAGACTGTAGTTTAGCTT和AAACAAGCTAAACTACAGTCTGTA),在CGI(位于区域5'端的 CpG 岛)附近插入loxP序列。来源:(J:331751)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count