在exon 1上游插入了一个带有loxP位点的frt flanked neo cassette,同时在exon 1下游也插入了一个loxP位点。通过flp介导的重组去除了neo cassette,随后cre介导的重组移除了exon 1。(来源:J:330969)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count