在Trbd1基因上游9-11个由DNA酶1敏感位点组成的3kbKpnI-AccI限制序列被替换为含诺卡因抗性基因座的loxP序列,接着是预设计的Trbd1/Trbj2-5片段序列,以及第三个loxP位点。随后通过Cre介导的重组,删除了neo cassette和插入的基因片段。(来源:J:54060)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S4/SvJae
Targeted
Insertion, Intergenic deletion
--
--
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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