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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Rr149350
tm1.2Che
Alias:
deltaPDbeta1
K.O. (deltaneo)
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基础信息
表型特征
文献报道
在Trbd1基因上游9-11个由DNA酶1敏感位点组成的3kbKpnI-AccI限制序列被替换为含诺卡因抗性基因座的loxP序列,接着是预设计的Trbd1/Trbj2-5片段序列,以及第三个loxP位点。随后通过Cre介导的重组,删除了neo cassette和插入的基因片段。(来源:J:54060)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
7388303
129S4/SvJae
Targeted
Insertion, Intergenic deletion
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--
--
2
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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