TALEN导向产生了一个位于chr7:142217981(GRCh39)的G到A点突变,这个位置在一个由多个物种共享的保守序列中,这个序列被转录抑制因子ZBED6结合。同时,随机发生了一个插入/复制单个胞嘧啶的变异,从C变为CC,位于chr7:142217984。(来源:J:331260)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
Insertion, Single point
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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