这个转基因是通过将全长的Mpl剪接变异体(cDNA)克隆到HS321/45-vav载体中实现的,载体包含了小鼠的Vav1基因组性序列。Mpl的剪接变异体在N端区域缺失了7个氨基酸。这条线携带有大约6个拷贝的转基因,且在多代中拷贝数保持稳定,但转基因插入的位置尚未得到确认。(来源:J:331302)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F1
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插入
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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