使用CRISPR/Cas9技术,针对I类嗅觉受体嗅觉感觉神经元(OSN)增强子,我们设计并应用了sgRNAs,目标序列包括CACCGTCTCATTGCCACCCGGATGA、AAACTCATCCGGGTGGCAATGAGAC、CACCGCCCCTCCACCGTACTTGCA和AAACTGCAAGTACGGTGGAGGGGC,实现了1982bp的缺失。(来源:J:254398)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x C3H)F1
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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