在exon 1上游插入了loxP位点,通过同源重组在exon 2下游插入了loxP和FRT标记的neo cassette。通过Flp介导的重组,neo cassette被移除,exons 1和2被留下了门控区域。随后,Cre介导的重组去除掉了exons 1和2。(来源:J:242006)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S/SvEv)F1
Targeted
插入,基因内删除
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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