邻近的心脏CACNA1G和EPN3增强子,位于CACNA1G内一个 intron 中,通过CRISPR/Cas9 技术用sgRNAs(针对GGGCCACATCCCTCAGCAGCC和GGCCCAATTAGAAGCCACCC)进行了靶向,产生了3345bp的缺失。(来源:J:295904)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count