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CRISPR/Cas9 technology introduced a premature termination codon (ACGT to TTAA change) in exon 5 at residue 271 to generate a truncation mutation in the alphaC region of fibrinogen. Plasma fibrinogen levels in homozygotes are approximately 10% of wild-type levels. The mutant fibrinogen is able to assemble into a mature fibrinogen molecule. Two lines, A and B were generated. Two lines, A and B were generated. This record represents line B. (J:330337)