通过CRISPR/Cas9技术,针对Nppa/Nppb超增强子,使用了sgRNAs,目标序列是GGCTTTTAACTTTACTGTTT和GGTTAATTGATTAAAAGTGG,实现了Rr103615和Rr93032两个增强子的消除。(来源:J:309962)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/NRj
Endonuclease-mediated
基因间区删除
--
2
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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