Grem1基因的调控区RR285(CRM2),位于Fmn1内含子15,通过CRISPR/Cas9技术,用sgRNAs针对AGCGGCAGTTCGGCTTCCGG和TCTCATACGATCCAGGAGAA设计,实现了9.9kb的删除,这个区域从染色体2的113,519,948到113,529,818(GRCm39),包含了内含子14和15,以及外显子15(J:312378)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Applicable
Endonuclease-mediated
基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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