Rr278^em1Flc

This CHD4/GATA4/NKX2-5/TBX5-binding site-containing 414 bp cis-regulatory element (CRE) in Myh11 intron 3, suppressing Myh11 expression, was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in the deletion of the GATA-binding region all four transcription factors bind to. (J:324708)