这个Vsx2增强子通过sgRNAs(ACAGCUAAUUAGAAGCCUAC和CCUGCCGAUAAUGCUUAAUU)以及ssODN模板(CCCACACAATGGTCTGCTTTGTGCCCACCTGCCGATAATGCTTAGGCGAGGAGTTGATTAATTTGAGGTAATTGACAGCTAGAAGCCTACAGGCTCATTAACTTGACATCTTGTCTTTGTGAATTGG)使用CRISPR/Cas9技术被靶向,成功地去除了两个Vsx2的共识结合位点。(来源:J:328714)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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