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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Trp53
tm6.1Glo
Alias:
Trp53
wm-R245W
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基础信息
表型特征
文献报道
在第7外显子的第245位,通过在第733位的C变为T和第735位的C变为G的替换,引入了赖氨酸到色氨酸(Arg到Trp,p.R245W)。此外,内含子6中插入了loxP位点、野生型p53第7-11外显子、原生的poly(A)信号序列以及FRT序列包裹的PGK抗药性基因座,以及另一个loxP位点。随后,通过Flp介导的重组移除了PGK抗药性基因 cassette。这段信息出自文献(J:268678)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
7341396
129S7/SvEvBrd-Hprt1+
Targeted
Insertion, Nucleotide substitutions
--
1
65
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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