这个Vsx2增强子通过sgRNAs( GUUAGACCUAGUCAGAACUC和GCAGGCCAUGUGCUCGUCGA)以及ssODN模板(TGTAATACCTGTAGTGGCCAGAAGAGGGCATCAGATCCCCAGGAGCTGGAGTACCTACATCTTTGGTTGGTGGTTCAGTCTCTGAGAGCCCCAGGGGCCCAGGTTTGTTGACTCTGTTGG)使用CRISPR/Cas9技术被定向编辑,产生了998bp的缺失,位置在chr12:84578818-84579815,参照GRCm39。(来源:J:328714)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count