在Ins2启动子的GG2-GG1/A2-C1增强子元件上,通过CRISPR/Cas9技术应用了sgRNAs,目标是CTTTCTGCAGACCTAGCACCAGG和AAACTGCAGCTTCAGCCCCTCTGG,这导致了一个15bp的缺失(序列CCAGGGAAGTGTTTG),去除了GG2,并部分割舍了GG1/A2元件。(来源:J:312429)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count