在Ins2启动子的GG2-GG1/A2-C1增强子元件上,通过CRISPR/Cas9技术应用了sgRNAs,目标是CTTTCTGCAGACCTAGCACCAGG和AAACTGCAGCTTCAGCCCCTCTGG,这导致了一个15bp的缺失(序列CCAGGGAAGTGTTTG),去除了GG2,并部分割舍了GG1/A2元件。(来源:J:312429)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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