Ins1基因启动子的GG2-GG1/A2增强子区域通过CRISPR/Cas9技术,使用sgRNAs针对CTTTCTGCAGACCTAGCACCAGG和AAACTGCAGCTTCAGCCCCTCTGG设计,实现了28bp的缺失,删除了整个GG2-GG1/A2元件,原文出自文献(J:312429)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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