将Shh增强子ZRS或MFCS1(哺乳动物和鱼保守序列1)的位置,位于Lmbr1的第五个内含子中,用等长的1324bp同源冷泉鱼序列(JH127332:522,984-524,307,latCha1)替换,通过sgRNA(靶向AGTACCATGCGTGTGTGTGA)和CRISPR/Cas9技术的质粒DNA模板进行操作。来源:(J:316049)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count