在DNA中,一个loxP位点、野生型的11/12号外显子、FRT引导的诺卡因选择性载体、另一个loxP位点,以及12号外显子中替换为氨基酸438由异亮氨酸变为赖氨酸(p.I438K)的11/12号区域,这些替换了原有的11和12号外显子。诺卡因载体通过Flp介导的重组被移除。(来源:J:308554)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
Insertion, Nucleotide substitutions
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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