在exon 4的上游插入了一个loxP位点。随后,一个3'带有loxP位点的FRT引导的neo cassette被插入在exon 7的下游。通过Flp介导的重组移除了neo cassette,使得exons 4-7周围留下了loxP位点。(来源:J:174871)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count